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Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis – News-Medical.net

Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA),…

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Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA), psoriasis andmultiple sclerosis(MS).
The authors designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents. 2-Acrylamidobenzoic acid analog11was identified as the lead compound for structure-activity relationship (SAR) studies.
The replacement of thephenyl group with naphthylmoieties…

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