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N439K mutation of SARS-CoV-2 may be more infectious and antibody resistant than Wuhan strain – News-Medical.Net

Researchers from the Harbin Institute of Technology, China, modeled the complexes formed between the RBD and the human ACE2 and monoclonal antibodies.



Researchers investigated the effect of different mutations of SARS-CoV-2 on its binding to the human angiotensin-converting enzyme 2 using molecular dynamics simulations. They found the N439K mutant binds more strongly than the original Wuhan strain, which may have implications for therapeutics like monoclonal antibodies.
The coronavirus disease 2019 (COVID-19) pandemic raging across the world is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The receptor-binding domain…

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