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Pressurized DNA state inside herpes capsids—A novel antiviral target

Author summary This work presents a proof-of-concept for anti-herpes treatment based on a novel mechanism of action that interferes with ejection of herpes genome into a host cell by perturbing the viral genome pressure inside the virus’ protein shell, termed…

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Citation: Brandariz-Nuñez A, Robinson SJ, Evilevitch A (2020) Pressurized DNA state inside herpes capsidsA novel antiviral target. PLoS Pathog 16(7):
e1008604.
https://doi.org/10.1371/journal.ppat.1008604
Editor: Donna Neumann, LSU Eye Center Department of Ophthalmology, UNITED STATES
Received: December 16, 2019; Accepted: May 5, 2020; Published: July 23, 2020
Copyright: © 2020 Brandariz-Nuñez et al. This is an open access article distributed under the terms of the Creative Commons Attribu…

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